MARINE GENOMICS

Understanding biological importance by evolutionary analyses of genomes, gene expression, and genetic divergence

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    Ph.D. Candidate, Marine Biology and Ecology

    University of Miami

    Rosenstiel School Marine and Atmospheric Sciences

     

    I am interested in 1) examining the effects of chronic anthropogenic pollution on the oxidative phosphorylation pathway (OxPhos) function and gene expression in hepatocytes from natural populations of the estuarine teleost, Fundulus heteroclitus, and 2) correlating any phenotypic changes with individual genotypes. Multiple F. heteroclitus populations have developed tolerance to pollutants at a variety of contaminated sites, and the central question we ask is, what differences in OxPhos function and gene expression appear to be affected by anthropogenic stressors, thus potentially being evolutionarily important for natural populations’ resistance to those stressors. To answer this question requires quantification of condition specific gene expression and metabolic function with biological replication, and an understanding of how gene expression affects metabolic function and how the underlying genotypes differ within and among natural populations adapted to different environments.

     

    Email: xdu@rsmas.miami.edu

     

    Publications

     

     Du, X., Crawford, D.L., Oleksiak, M.F., 2015. Effects of Anthropogenic Pollution on the Oxidative Phosphorylation Pathway of Hepatocytes from Natural Populations of Fundulus heteroclitus. Aquatic Toxicology 165, 231-240.

    Xiao Du

    Funhe-Evol.org - Laboratory of Marine Genomics at the University of Miami

    Principal Investigators: Dr. Marjorie Oleksiak & Dr. Douglas Crawford

                                                 Conatct Information: moleksiak@rsmas.miami.edu or dcrawford@rsmas.miami.edu                                             

    Updated: 2016